San Francisco's perfect record meets defending champion Seattle in a Sunday clash that could define the NFC West race.
The NFC West's fiercest rivalry returns on Sunday 11 October, and the stakes are big. The unbeaten 49ers travel to Seattle to face a 3-1 Seahawks side, in a game that could decide who leads the division as the season enters its second quarter.
The history makes it even better. Last season, these two teams met twice with everything on the line. Seattle won the regular-season finale in the Bay Area to take the NFC West title and homefield advantage. They then crushed San Francisco 41-6 in the divisional round at home. That result launched a playoff run that ended with a Super Bowl title, while the Niners watched from the couch.
Now the 49ers have a chance to answer back. They arrive with a perfect record and a point to prove against the team that ended their season. Seattle have stayed steady despite a scare in Week 1, when quarterback Sam Darnold was injured early and missed a game. The Seahawks kept winning without him and have looked like a champion since.
The winner takes more than one result. They become the early favourite in the division and gain a head-to-head tiebreaker, which could matter a great deal in the NFL's most competitive division. Check your local listings for broadcast and live stream options in your region, and settle in for what should be one of the biggest games of the season so far.